Study Publications

  1. Pausova Z, Paus T, Abrahamowicz M, Almerigi J, Arbour N, Bernard M, Gaudet D, Hanzalek P, Hamet P, Evans AC, Kramer M, Laberge L, Leal S, Leonard G, Lerner J, Lerner RM, Mathieu J, Perron M, Pike B, Pitiot A, Richer L, Séguin JR, Syme C, Toro R, Tremblay RE, Veillette S, Watkins K. Genes, Maternal Smoking and the Offspring Brain and Body during Adolescence: Design of The Saguenay Youth Study. Human Brain Mapping 28:502-518, 2007.
  2. Paus T, Toro R, Leonard G, Lerner J, Lerner RM, Perron M, Pike GB, Richer L, Steinberg, Veillette S, Pausova Z. Morphological properties of the action-observation cortical network in adolescents with low and high resistance to peer influence. Social Neuroscience 3:303-316, 2008.
  3. Toro R, Leonard G, Lerner JV, Lerner RM, Perron M, Pike GB, Richer L, Veillette S, Pausova Z., Paus T. Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortex. Neuropsychopharmacology 33:1019-27, 2008.
  4. Paus T, Nawazkhan I, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Veillette S, Pausova Z. Corpus Callosum in Adolescent Offspring Exposed Prenatally to Maternal Cigarette Smoking. NeuroImage 40:435-441, 2008.
  5. Syme C, Abrahamowicz M, Leonard G, Pitiot A, Perron M, Qiu X, Richer L, Totman J, Veillette V, Gaudet D, Paus T, Pausova Z. Intra-abdominal adiposity and the metabolic syndrome in adolescence: Gender differences and underlying mechanisms. Archives of Pediatrics & Adolescent Medicine 162:453-61, 2008.
  6. Toro R, Perron M, Pike B, Richer R, Veillette S, Pausova Z, Paus T. Brain size and folding of the human cerebral cortex. Cerebral Cortex 18:2352-7, 2008.
  7. Perrin JS, Herve PY, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Veillette S, Pausova Z., Paus T. Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor. Journal of Neuroscience 28:9519-9524, 2008.
  8. Kafouri S, Leonard G, Perron M, Richer L, Séguin JR, Veillette S, Pausova Z., Paus T Maternal Cigarette Smoking During Pregnancy and Cognitive Performance in Adolescence. International Journal of Epidemiology 38:158-72, 2009.
  9. Herve PY, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Veillette S, Pausova Z., Paus T Handedness, motor skills and maturation of the corticospinal tract in the adolescent brain. Human Brain Mapping 30:3151-3162, 2009.
  10. Perrin JS, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Veillette S, Pausova Z., Paus T. Sex differences in the growth of white matter during adolescence NeuroImage 45:1055-1066, 2009.
  11. Toro R, Chupin M, Garnero L, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Veillette S, Pausova Z., Paus T. Brain volumes and Val66Met polymorphism of the BDNF gene: Local or global effects? Brain Structure and Function 213:501-509, 2009.
  12. Syme C, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Xiao Y, Gaudet D, Paus T, Pausova Z. Sex differences in blood pressure and its relationships to body composition and metabolic health in adolescence. Archives of Pediatrics & Adolescent Medicine 163:818-825, 2009.
  13. Pausova Z, Syme C, Abrahamowicz M, Xiao Y, Leonard G, Perron M, Richer L, Veillette S, Davey Smith G, Seda O, Tremblay J, Hamet P, Gaudet D, Paus T. A common variant of the FTO gene is associated not only with increased adiposity but also with elevated blood pressure in French-Canadians. Circulation: Cardiovascular Genetics 2:260-269, 2009.
  14. Lotfipour S, Ferguson E, Leonard G, Perron M, Pike GB, Richer L, Séguin JR, Toro R, Veillette S, Pausova Z., Paus T. Orbitofrontal Cortex and Drug Use during Adolescence: Role of Prenatal Exposure to Maternal Smoking and BDNF Genotype. Archives of General Psychiatry 66:1244-1252, 2009.
  15. Lotfipour S, Leonard G, Perron M, Pike GB, Richer L, Séguin JR, Toro R, Veillette S, Pausova Z., Paus T. Prenatal Exposure to Maternal Cigarette Smoking Interacts With a Polymorphism in the α6 Nicotinic Acetylcholine Receptor Gene to Influence Drug Use and Striatum Volume in Adolescence. Molecular Psychiatry 15:6-8, 2010.
  16. Paus T, Nawaz-Khan I, Leonard G, Perron M, Pike GB, Pitiot A, Richer L, Susman E, Veillette S, Pausova Z. Sexual Dimorphism in the Adolescent Brain: Role of Testosterone and Androgen Receptor in Global and Local Volumes of Grey and White Matter. Hormones and Behavior 57:63-75, 2010.
  17. Syme C, Abrahamowicz M, Mahboubi A, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Prenatal Exposure to Maternal Cigarette Smoking and Intra-Abdominal Accumulation of Fat during Adolescence. Obesity 18:1021-5, 2010.
  18. Pausova Z, Abrahamowicz M, Mahboubi A, Syme C, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T. Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescents. Hypertension 55:706-14, 2010.
  19. Toledo-Rodriguez M, Lotfipour S, Leonard G, Perron M, Richer L, Veillette S, Pausova Z., Paus T Maternal Smoking During Pregnancy Is Associated with Epigenetic Modifications of the
Brain Derived Neurotrophic Factor-6 Exon in Adolescent Offspring. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B:1350-4, 2010.
  20. Chakravarty MM, Aleong R, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Automated analysis of craniofacial morphology using magnetic resonance images. PLoS ONE 6:e20241, 2011.
  21. Melka MG, Bernard M, Mahboubi A, Abrahamowicz M, Paterson AD, Syme C, Lourdusamy A, Schumann G, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure. The Journal of Clinical Endocrinology & Metabolism 97:E145-50, 2012.
  22. Paus T, Bernard M, Chakravarty MM, Davey Smith G, Gillis J, Lourdusamy A, Leonard G, Melka MG, Pavlidis P, Perron M, Pike GB, Richer L, Schumann G, Timpson N, Toro R, Veillette S, Pausova Z. KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study. Cerebral Cortex 22:2634-42, 2012.
  23. Marečková K, Weinbrand Z, Chakravarty MM, Lawrence C, Aleong R, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Testosterone-mediated sex differences in the face shape during adolescence: Subjective impressions and objective features. Hormones and Behavior 60:681-90, 2011.
  24. Pausova Z, Mahboubi A, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T. Sex differences in the contributions of visceral and total body fat to blood pressure in adolescence. Hypertension 59:572-9, 2012.
  25. Haghighi A, Schwartz DH, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Prenatal exposure to maternal cigarette smoking, amygdala volume and fat intake in adolescence. JAMA Psychiatry 70:98-105, 2013.
  26. Liu F, van der Lijn F, Schurmann C, Zhu G, Chakravarty MM, Hysi PG, Wollstein A, Lao O, de Bruijne M, Ikram MA, van der Lugt A, Rivadeneira F, Uitterlinden AG, Hofman A, Niessen WJ, Homuth G, de Zubicaray G, McMahon KL, Thompson PM, Daboul A, Puls R, Hegenscheid K, Bevan L, Pausova Z, Medland SE, Montgomery GW, Wright MJ, Wicking C, Boehringer S, Spector TD, Paus T, Martin NG, Biffar R, Kayser M. A genome-wide association study identifies five loci influencing facial features in populations of European ancestry. PLoS Genetics 8:e1002932, 2012.
  27. Kafouri S, Kramer M, Leonard G, Perron M, Pike GB, Richer L, Toro R, Veillette S, Pausova Z, Paus T. Breastfeeding and brain structure in adolescence. International Journal of Epidemiology 42:150-9, 2012.
  28. Haghighi A, Melka MM, Bernard M, Abrahamowicz M, Leonard GT, Richer L, Perron M, Veillette S, Xu CJ, Greenwood CMT, Dias A, El-Sohemy A, Gaudet D, Paus T, Pausova Z. Opioid receptor mu 1 gene, fat intake and obesity in adolescence. Molecular Psychiatry 19:63-8, 2014.
  29. Melka MG, Gillis J, Bernard M, Abrahamowicz M, Chakravarty MM, Leonard GT, Perron M, Richer L, Veillette S, Banaschewski T, Barker GJ, Büchel C, Conrod P, Flor H, Heinz A, Garavan H, Brühl R, Mann K, Artiges E, Lourdusamy A, Lathrop M, Loth E, Schwartz Y, Frouin V, Rietschel M, Smolka MN, Ströhle A, Gallinat J, Struve M, Lattka E, Waldenberger M, Schumann G, Pavlidis P, Gaudet D, Paus T, Pausova Z. FTO, obesity and the adolescent brain. Human Molecular Genetics 22:1050-8, 2012.
  30. Marecková K, Chakravarty M, Huang M, Lawrence C, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Does skull shape mediate the relationship between objective features and subjective impressions about the face? NeuroImage 79:234-240, 2013.
  31. Khairullah A, May M, Tilling K, Howe LD, Leonard G, Perron M, Richer L, Veillette S, Pausova Z, Paus T. Height-based Indices of Pubertal Timing in Male Adolescents. International Journal of Developmental Science 7:105-116, 2013.
  32. Schwartz DH, Leonard G, Perron M, Richer L, Syme C, Veillette S, Pausova Z, Paus T. Visceral fat is associated with lower executive functioning in adolescents. International Journal of Obesity 37:1336-1343, 2013.
  33. Goodwin K, Syme C, Abrahamowicz M, Leonard GT, Richer L, Perron M, Veillette S, Gaudet D, Paus T, Pausova Z. Routine clinical measures of adiposity as predictors of visceral fat in adolescence: a population-based magnetic resonance imaging study. PLoS One 8:e79896, 2013.
  34. Melka MG, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Clustering of the metabolic syndrome components in adolescence: role of visceral fat. PLoS One. 8:e82368, 2013.
  35. Gestsdóttir S, Geldhof J, Paus T, Freund AM, Aðalbjarnardóttir S, Lerner JV, Lerner RM. Self-regulation among youth in four Western cultures: Is there an adolescence-specific structure of the Selection-Optimization-Compensation (SOC) model? International Journal of Behavioral Development (in press).
  36. Lotfipour S, Ferguson E, Leonard G, Miettunen J, Perron M, Pike GB, Richer L, Séguin JR, Veillette S, Jarvelin MR, Moilanen I, Mäki P, Nordström T, Pausova Z, Veijola J, Paus T. Maternal Cigarette Smoking during Pregnancy Predicts Drug Use Via Externalizing Behavior in Two Community-based Samples of Adolescents. Addiction 109:1718-29, 2014.
  37. Marecková K, Chakravarty M, Lawrence C, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development. Brain Structure and Function 220:3233-44, 2015.
  38. Schwartz DH, Dickie E, Pangelinan MM, Leonard G, Perron M, Richer L, Veillette S, Pausova Z, Paus T. Adiposity is associated with structural properties of the adolescent brain. NeuroImage 103:192-201, 2014.
  39. Lee KW, Richmond R, Hu P, French L, Shin J, Bourdon C, Reischl E, Waldenberger M, Zeilinger S, Gaunt T, McArdle W, Ring S, Woodward G, Bouchard L, Gaudet D, Davey-Smith G, Relton C, Paus T, Pausova Z. Prenatal Exposure to Maternal Cigarette Smoking and DNA Methylation: Epigenome-Wide Association in a Discovery Sample of Adolescents and Replication in an Independent Cohort at Birth through 17 Years of Age. Environmental Health Perspectives 123:193-9, 2015.
  40. Paus T, Pausova Z, Abrahamowicz M, Gaudet D, Leonard G, Pike GB, Richer L. Saguenay Youth Study: A multi-generational approach to studying virtual trajectories of the brain and cardio-metabolic health. Developmental Cognitive Neuroscience 11:129-44, 2015.
  41. Pangelinan MM, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Puberty and testosterone shape the corticospinal tract during male adolescence. Brain Structure and Function 221:1083-94, 2016.
  42. Lee KWK, Abrahamowicz M, Leonard GT, Richer L, Perron M, Veillette S, Reischl E, Bouchard L, Gaudet D, Paus T, Pausova Z. Prenatal exposure to cigarette smoke interacts with OPRM1 to modulate dietary preference for fat. Journal of Psychiatry & Neuroscience 40:38, 2015.
  43. Van Woudenberg M, Shin J, Bernard M, Syme C, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence. International Journal of Hypertension 10:395-402, 2015.
  44. French L, Gray C, Leonard G, Perron M, Pike GB, Richer L, Séguin JR, Veillette S, Evans JC, Artiges E, Banaschewski T, Bokde A, Bromberg U, Bruehl R, Büchel C, Cattrel A, Conrod P, Flor H, Frouin V, Gallinat, Garavan H, Gowland P, Heinz A, Lemaitre H, Martinot JL, Nees F, Papadopoulos D, Pangelinan M, Poustka L, Rietschel M, Smolka MN, Walter H, Whelan R, Timpson NJ, Schumann G, Davey Smith G, Pausova Z, Paus T. Early cannabis use, polygenic risk score for schizophrenia and brain maturation in adolescence. JAMA Psychiatry 72:1002-11, 2015.
  45. Shin J, Bourdon C, Bernard M, Wilson M, Reischl E, Waldenberger M, Ruggeri B, Schumann G, Desrivieres S, Leemans A, the IMAGEN Consortium, the SYS Consortium, Abrahamowicz M, Leonard G, Richer L, Bouchard L, Gaudet D, Paus T, Pausova Z. Layered genetic control of DNA methylation and gene expression: a locus of multiple sclerosis in healthy individuals. Human Molecular Genetics 24:5733-45, 2015.
  46. Pausova Z, Paus T, Abrahamowicz M, Bernard M, Gaudet D, Leonard G, Perron M, Pike GB, Richer L, Seguin JR, Veillette S. Cohort Profile: The Saguenay Youth Study (SYS). International Journal of Epidemiology 46:e19, 2017.
  47. Cáceres A, Esko T, Pappa I, Gutiérrez A, Lopez-Espinosa MJ, Llop S, Bustamante M, Tiemeier H, Metspalu A, Joshi PK, Wilsonx JF, Reina-Castillón J, Shin J, Pausova Z, Paus T, Sunyer J, Pérez-Jurado LA, González JR Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children’s Intelligence. PloS One, 11:e0157739, 2016.
  48. Markova D, Richer L, Pangelinan M, Schwartz DH, Leonard G, Perron M, Pike GB, Veillette S, Chakravarty MM, Pausova Z, Paus T. Age- and Sex-related Variations in Vocal-Tract Morphology and Voice Acoustics during Adolescence. Hormones and Behavior 81:84-96, 2016.
  49. Ramsay H, Barnett JH, Murray GK, Mäki P, Hurtig T, Nordström T, Miettunen J, Kiviniemi V, Niemelä S, Pausova Z, Paus T, Veijola J. Smoking in pregnancy, adolescent mental health and cognitive performance in young adult offspring: results from a matched sample within a Finnish cohort. BMC Psychiatry16:430, 2016.
  50. Paus T, Wong AP, Syme C, Pausova Z. Sex differences in the adolescent brain and body: Findings from the Saguenay Youth Study. Journal of Neuroscience Research 95:362-370, 2017.
  51. Syme C, Czajkowski S, Shin J, Abrahamowicz M, Leonard G, Perron M, Richer L, Veillette S, Gaudet D, Strug L, Wang Y, Xu H, Taylor G, Paus T, Bennett S, Pausova Z. Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents: A Cohort Study. Circulation 134:1629-1636, 2016.
  52. Wong APY, French L, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain. Cerebral Cortex (in press).
  53. Parker N, Wong APY, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Income inequality, gene expression, and brain maturation during adolescence. Scientific Reports 7:7397, 2017.
  54. Shin J, French L, Xu T, Leonard G, Perron M, Pike GB, Richer L, Veillette S, Pausova Z, Paus T. Cell-specific gene-expression profiles and cortical thickness in the human brain. Cerebral Cortex (in press).
  55. Axelrud LK, Santoro ML, Pine DS, Talarico F, Gadelha A, Manfro GG, Pan PM, Jackowski A, Picon F, Brietzke E, Grassi-Oliveira R, Bressan RA, Miguel EC, Rohde LA, Hakonarson H, Pausova Z, Belangero S, Paus T, Salum GA. Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. American Journal of Psychiatry (in press)
  56. Huguet G, Schramm C, Douard E, Jiang L, Labbe A, Tihy F, Mathonnet G, Nizard S, Lemyre E, Mathieu A, Poline JB, Loth E, Toro R, Schumann G, Conrod P, Pausova Z, Greenwood C, Paus T, Bourgeron T, Jacquemont S; IMAGEN Consortium. Measuring and Estimating the Effect Sizes of Copy Number Variants on General Intelligence in Community-Based Samples. JAMA Psychiatry (in press)

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