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Study Publications

Study Publications:

Original papers based upon the SYS dataset

Pausova, Z., Paus, T., Abrahamowicz, M., Almerigi, J., Arbour, N., Bernard, M. et al. (2007). Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study. Human Brain Mapping, 28, 502-518.

Paus, T., Nawazkhan, I., Leonard, G., Perron, M., Pike, G. B., Pitiot, A. et al. (2008). Corpus callosum in adolescent offspring exposed prenatally to maternal cigarette smoking. Neuroimage., 40, 435-441.

Perrin, J. S., Herve, P. Y., Leonard, G., Perron, M., Pike, G. B., Pitiot, A. et al. (2008). Growth of white matter in the adolescent brain: role of testosterone and androgen receptor. Journal of Neuroscience, 28, 9519-9524.

Syme, C., Abrahamowicz, M., Leonard, G. T., Perron, M., Pitiot, A., Qiu, X. et al. (2008). Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms. Archives of Pediatrics and Adolescent Medicine, 162, 453-461.

Toro, R., Leonard, G., Lerner, J. V., Lerner, R. M., Perron, M., Pike, G. B. et al. (2008). Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortex. Neuropsychopharmacology, 33, 1019-1027.

Toro, R., Perron, M., Pike, B., Richer, L., Veillette, S., Pausova, Z. et al. (2008). Brain size and folding of the human cerebral cortex. Cerebral Cortex, 18, 2352-2357.

Herve, P. Y., Leonard, G., Perron, M., Pike, B., Pitiot, A., Richer, L., Veilliette, S., Pausova, Z., Paus, T. (2009). Handedness, motor skills and maturation of the corticospinal tract in the adolescent brain. Human Brain Mapping, 30, 3151-3162.

Kafouri, S., Leonard, G., Perron, M., Richer, L., Seguin, J. R., Veillette, S. et al. (2009). Maternal cigarette smoking during pregnancy and cognitive performance in adolescence. International Journal of Epidemiology, 38, 158-172.

Lotfipour, S., Ferguson, E., Leonard, G., Perron, M., Pike, B., Richer, L., Seguin, J.R., Toro, R., Veillette, S., Pausova, Z., Paus, T. (2009). Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype. Archives of General Psychiatry, 66, 1244-1252.

Pausova, Z., Syme, C., Abrahamowicz, M., Xiao, Y., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Davey Smith, G., Seda, O., Tremblay, J., Hamet, P., Gaudet, D., Paus, T. (2009). A common variant of the FTO gene is associated not only with increased adiposity but also elevated blood pressure in French Canadians. Circulation: Cardiovascular Genetics, 2, 260-269.

Paus T and Toro R. Could sex differences in white matter be explained by g ratio? Frontiers in Neuroanatomy, 3, 14, 2009.

Perrin, J. S., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., Paus, T. (2009). Sex differences in the growth of white matter during adolescence. Neuroimage., 45, 1055-1066.

Syme, C., Abrahamowicz, M., Mahboubi, A., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Gaudet, D., Paus, T., Pausova, Z. (2010). Prenatal Exposure to Maternal Cigarette Smoking and Accumulation of Intra-abdominal Fat During Adolescence. Obesity, 18, 1021-1025.

Syme, C., Abrahamowicz, M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Xiao, Y., Gaudet, D., Paus, T., Pausova, Z. (2009). Sex differences in blood pressure and its relationship to body composition and metabolic health in adolescence. Archives of Pediatrics and Adolescent Medicine, 163, 818-825.

Toro, R., Chupin, M., Garnero, L., Leonard, G., Perron, M., Pike, B., Pitiot, A., Richer, L., Veillette, S., Pausova, Z., Paus, T. (2009). Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects? Brain Structure and Function, 213, 501-509.

Lotfipour, S., Leonard, G., Perron, M., Pike, B., Richer, L., Seguin, J. R., Toro, R., Veillette, S., Pausova, Z., Paus, T. (2010). Prenatal exposure to maternal cigarette smoking interacts with a polymorphism in the alpha6 nicotinic acetylcholine receptor gene to influence drug use and striatum volume in adolescence. Molecular Psychiatry, 15, 6-8.

Paus, T., Nawaz-Khan, I., Leonard, G., Perron, M., Pike, G. B., Pitiot, A., Richer, L., Susman, E., Veillete, S., Pausova, Z. (2010). Sexual dimorphism in the adolescent brain: Role of testosterone and androgen receptor in global and local volumes of grey and white matter. Hormones and Behaviour, 57, 63-75.

Pausova, Z., Abrahamowicz, M., Mahboubi, A., Syme, C., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Gaudet, D. Paus, T. (2010). Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescents. Hypertension, 55, 706-714.

Syme, C., Abrahamowicz, M., Mahboubi, A., Leonard, G. T., Perron, M., Richer, L. et al. (2010). Prenatal exposure to maternal cigarette smoking and intra-abdominal accumulation of fat during adolescence. Obesity, 18, 1021-1025.

Toledo-Rodriguez, M., Lotfipour, S., Leonard, G., Perron, M., Richer, L., Veillette, S. et al. (2010). Maternal Smoking During Pregnancy Is Associated with Epigenetic Modifications of the
Brain Derived Neurotrophic Factor-6 Exon in Adolescent Offspring. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B, 1350-1354.

Chakravarty, M.M., Aleong, R., Leonard, G., Perron, M., Pike, G.B., Richer, L., Veillette, S., Pausova, Z., Paus, T. (2011). Automated analysis of craniofacial morphology using magnetic resonance images. PLoS ONE, 6, e20241.

Mareckova, K., Weinbrand, Z., Chakravarty, M.M., Lawrence, C., Aleong, R., Leonard, G., Perron, M., Pike, G.B., Richer, L., Veillette, S., Pausova, Z., Paus, T. (2011). Testosterone-mediated sex differences in the face shape during adolescence: Subjective impressions and objective features. Hormones and Behaviour, 60, 681-690.

Haghighi, A., Schwartz, D.H., Abrahamowicz, M., Leonard, G.T., Perron, M., Richer, L., Veillette, S., Gaudet, D., Paus, T., Pausova, Z. (in press). Prenatal exposure to maternal cigarette smoking, amygdala volume and fat intake in adolescence. Archives of General Psychiatry.

Liu, F., van der Lijn, F., Schurmann, C., Zhu, G., Chakravarty, M.M., Hysi, P.G., Wollstein, A., Lao, O., de Bruijne, M., Ikram, M.A., van der Lugt, A., Rivadeneira, F., Uitterlinden, A.G., Hofman, A., Niessen, W.J., Homuth, G., de Zubicaray, G., McMahon, K.L., Thompson, P.M., Daboul, A., Puls, R., Hegenscheid, K., Bevan, L., Pausova, Z., Medland, S.E., Montgomery, G.W., Wright, M.J., Wicking, C., Boehringer, S., Spector, T.D., Paus, T., Martin, N.G., Biffar, R., Kayser, M. (in press). A genome-wide association study identifies five loci influencing facial features in populations of European ancestry. PLoS Genetics.

Melka, M.G., Bernard, M., Mahboubi, A., Abrahamowicz, M., Paterson, A.D., Syme, C., Lourdusamy, A., Schumann, G., Leonard, G., Perron, M., Pike, G.B., Richer, L., Veillette, S., Gaudet, D., Paus, T., Pausova, Z. (2012). Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure. Journal of Clinical Endocrinology & Metabolism, 97, E145-150.

Paus, T., Bernard, M., Chakravarty, M.M., Davey Smith, G., Gillis, J., Lourdusamy, A., Leonard, G., Melka, M.G., Pavlidis, P., Perron, M., Pike, G.B., Richer, L., Schumann, G., Timpson, N., Toro, R., Veillette, S., Pausova, Z. (in press). KCTD8 gene and brain growth in adverse intrauterine environment: a genome-wide association study. Cerebral Cortex.

Pausova, Z., Mahboubi, A., Abrahamowicz, M., Leonard, G.T., Perron, M., Richer, L., Veilleette, S., Gaudet, D., Paus, T. (2012). Sex differences in the contributions of visceral and total body fat to blood pressure in adolescence. Hypertension, 59, 572-579.

Stein, J.L. et al. (2012). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44, 552-561.

Toledo-Rodriguez, M., Loyse, N., Bourdon, C., Arab, S., Pausova, Z. (2012). Effect of prenatal exposure to nicotine on kidney glomerular mass and AT1R expression in genetically diverse strains of rats. Toxicology Letters, 213, 228-234.

Kafouri S, Kramer M, Leonard G, Perron M, Pike GB, Richer L, Toro R, Veillette S, Pausova Z, Paus T. Breastfeeding and brain structure in adolescence. International Journal of Epidemiology (in press).

Haghighi A, Melka MM, Bernard M, Abrahamowicz M, Leonard GT, Richer L, Perron M, Veillette S, Xu CJ, Greenwood CMT, Dias A, El-Sohemy A, Gaudet D, Paus T, Pausova Z. Opioid receptor mu 1 gene, fat intake and obesity in adolescence. Molecular Psychiatry (in press).

 

Relevant review & chapters

Paus, T., Gächter, S., Starmer, C., Wilkinson, R. (2008). Cooperative behaviour, conflict resolution, and positive youth development. In: Lerner, R.M., Roeser R.W., and Phelps E., (Eds) Positive Youth Development and Spirituality: From Theory to Research. West Conshohocken, PA, Templeton Foundation Press.

Paus, T., Pausova, Z., Abrahamowicz, M., Almerigi, J., Arbour, N., Bernard, M., Gaudet, D., Hanzalek, P., Hamet, P., Evans, A.C., Kramer, M., Laberge, L., Leal, S., Leonard, G., Lerner, J., Lerner, R.M., Mathieu, J., Perron, M., Pike, B., Pitiot, A., Richer, L., Séguin, J.R., Syme, C., Toro, R., Tremblay, R.E., Veillette, S., Watkins, K. (2009). Genes, Maternal Smoking, genes and adolescent brain and body: The Saguenay Youth Study. In: van Aken, M.A,G., Tremblay, R.E., and Koops, W. Development and Prevention of behaviour problems: From genes to social policy, Psychology Press.

Paus, T., (2009). Brain Development. In: Lerner, R.M. and Steinberg, L. (Eds) Handbook of Adolescent Psychology, 3rd Edition, pp. 95-115, John Wiley & Sons.

Paus, T., (2010). Sex differences in the human brain: A developmental perspective. In: Savic, I. (Ed) Progress in Brain Research, Vol 186, pp. 13-28, Academic Press.

Paus, T., (2010). A primer for brain imaging: a tool for evidence-based studies of nutrition? Nutrition Reviews, 68, Suppl 1, S29-S37.

Paus, T., (2010). Growth of white matter in the adolescent brain: Myelin or axon. Brain and Cognition, 72, 26-35.

Paus, T., (2010). Population Neuroscience: Why and how. Human Brain Mapping, 31, 891-903.

Paus, T., Leonard, G., Lerner, J.V., Lerner, R.M., Perron, M., Pike, G.B., Richer, L., Toro, R., Veillette, S., Pausova, Z. (In press). Positive youth development and age-related changes in cortical thickness during adolescence. In: Warren, A.E.A., Lerner, R.M., Phelps, E. (Eds) Thriving and Spirituality Among Youth: Research Perspectives and Future Possibilities, Hoboken, N.J., John Wiley & Sons.